- 2000 – Library of Congress – The Library celebrates its bicentennial during the year, culminating in the actual anniversary date on April 24.
- 2001 – Library of Congress – The first National Book Festival, developed in cooperation with First Lady Laura Bush, takes place on Sept. 8.
- 2007 – Library of Congress – The new Packard Campus for Audio-Visual Conservation located on a 45-acre site in Culpeper, Virginia, is transferred to the Library by the Packard Humanities Institute on July 26. The Institute provided $155 million for the design and construction of the four-building facility, the largest private gift ever made to the Library.
- 2009 – Library of Congress – In Paris, Librarian James H. Billington announces on April 21 the launch of the World Digital Library, an international collaborative project developed with UNESCO and other organizations.
- 2012 – Library of Congress – BIBFRAME – In 2012, the Library of Congress announced that it had contracted with Zepheira, a data management company, to develop a linked data alternative to MARC. Later that year, the library announced a new model called MARC Resources (MARCR). That November, the library released a more complete draft of the model, renamed BIBFRAME.
- 2016 – Library of Congress – Carla D. Hayden is sworn in as the 14th Librarian of Congress on Sept. 14. At the time of her installation, the Library’s collection of more than 162 million items includes more than 38 million cataloged books and other print materials in more than 470 languages; more than 70 million manuscripts; the largest rare book collection in North America; and the world’s largest collections of legal materials, films, maps, sheet music, and sound recordings. In fiscal year 2016, the Library employed 3,149 staff members and operated with a total 2016 appropriation of $642.04 million, including the authorization to spend $43.13 million in receipts.
- 2016 – Library of Congress – BIBFRAME – The Library of Congress released version 2.0 of BIBFRAME in 2016.